Senior Scientist, Nonclinical DMPK

Key responsibilities

• Design, plan, manage, and report the nonclinical DMPK studies:
  • Exploratory DMPK studies to support innovation projects
  • In vitro and in vivo DMPK profiling to support lead optimisation and selection of drug development candidates
  • In vitro and in vivo DMPK (including toxicokinetics) regulatory and nonregulatory studies to characterise the ADME properties and the risk of drug-drug interactions of drugs in the development
  • Modelling and simulation of nonclinical data (such as allometric scaling, PBPK modelling, nonclinical PK/PD) to support human dose prediction
• Manage outsourcing activities to an international network of CROs or through academic collaborations (request for proposal, contractor selection, contract review, and budget negotiation)
• Manage finance, budget, and timelines related to assigned nonclinical DMPK activities
• Contribute to the preparation of the nonclinical DMPK documentation to support the cross-functional activities (including nonclinical DMPK chapters of regulatory documents or patents)
• Participate in external scientific communications (publications, poster, and oral presentations, and press releases)
• Contribute to in/out-licensing activities and external fund-raising activities (evaluation of new external opportunities, participation in due diligence and grant applications)

Your profile

• PhD, engineer degree or equivalent in pharmacokinetics, pharmacology, life sciences, or a related discipline with 5-7 years experience in nonclinical DMPK within Translational R&D
• Knowledge of GLP and ICH guidelines; animal welfare regulations
• Fluency in English (both oral and written)
• Very good communication skills & influencing skills (oral and written)
• Strong team player, looking to drive further projects and innovation
• Project management experience
• Team management and leadership experience is a plus